A GMCSF & IL15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signalling throughthe IL15 receptor complex Running title : GIFT15 Fusokine with Immunosuppressive Properties
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چکیده
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منابع مشابه
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
We hypothesized that a granulocyte macrophage colony-stimulating factor (GMCSF) and interleukin 15 (IL-15) fusokine (GIFT15) would possess greater immune-stimulatory properties than their combined use. Unexpectedly, tumor cells engineered to secrete GIFT15 protein led to suppression of natural killer (NK) and NKT-cell recruitment in vivo, suggesting an unanticipated immune-suppressive effect. W...
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